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JNTU IV Year B. Pharmacy II-Semester syllabus for MEDICINAL CHEMISTRY - III

(R7703) MEDICINAL CHEMISTRY - III
Note:
A study of the following classes of drugs including introduction, classification with examples of structures, mechanism of action, SAR and metabolism. Synthesis of compounds specified against each class is to be studied for the following UNITS

UNIT - I
Drugs acting on Cardio-vascular diseases:
General account of cardiovascular diseases
Antihypertensives - Methyldopa, amlodipine, enalapril, losartan.

UNIT - II
Anti-arrhythmics - Procainamide
Diuretics - Acetazolamide, hydrochlorthiazide, furosemide
Anticoagulants, Anti-anginals and Coronary vasodilators - Isosorbide dinitrate, verapamil, diltiazem


UNIT - III
Antihyperlipidemics (Hypocholesteremic drugs)- Clofibrate. A brief account on statins

General account on pancreatic and thyroid hormonal malfunctions.
Antidiabetics - Phenformin, Glipizide including a brief account on PPAR inhibitors, Meglitinide analogues,
?-Glucosidase inhibitors - Acarbose, Miglitol

Drugs affecting Thyroid Function: Methimazole, Propylthiouracil, Insulin preparations

UNIT - IV
Analgesics and NSAIDS (Non-steroidal anti-inflamatory agents):
i. Introduction and types of pain and inflammation
ii Classification and systematic development of analgesics of morphine, mild analgesics and strong analgesics: Meperidine and Methadone
iii. NSAIDS - Aspirin, paracetamol, oxyphenbutazone, ibuprofen, indomethacin, diclofenac and meloxicam
iv. A brief account on Cox-2 inhibitors and Nimsulide.

UNIT - V
Chemotherapeutic Agents:
Sulpha drugs - Sulphadiazine, Suphasalzine, Trimethoprim, Sulphamethoxazole, Sulphameter
Anti viral Drugs - Acyclovir, Zidovudine
Antifungal Agents - Fluconazole and Itraconazole.

UNIT - VI
Anti tubercular agents : Isonicotinic acid hydrazide and ethambutol,
Anti leprotic agents : Dapsone, clofazemine
Antiamoebics : Metronidazole, diloxanide furoate

UNIT - VII
Anthelmintics : Diethylcarbamazine citrate, pyrantel pamoate,
mebendazole, albendazole
Antimalarial drugs : Chloroquine, primaquine and pyrimethamine, norflaxacin and ciprofloxacin

UNIT - VIII
Anticancer Drugs : Chlorambucil, busulphan, procarbazine, carmustine, 5-flurouracil, 5-mercaptopurine methotrexate, vinca alkaloids - vinblastin, vincristine

TEXT BOOKS

1. William O. Foye, Textbook of Medicinal Chemistry by, Lea Febiger, Philadelphia.
2. JH Block & JM Beale, Wilson & Giswold's Textbook of organic Medicinal Chemistry and pharmaceutical chemistry by (Eds), 11th Ed, Lipcott, Raven, Philadelphia, 2004.
3. S. N. Pandeya, Textbook of mediacinal chemistry, SG Publ. Varanasi, 2003.
4. Rama Rao Nadendla, Medicinal Chemistry.

REFERENCES

1. D. Abraham (Ed), Burger Medicinal chemistry ad Drug discovery, Vol. 1 & 2. John Wiley & Sons, New York 2003, 6th Ed.
2. Lippincott Williams and Wilkins: Remington Pharmaceutical Sciences
3. L. M. Atherden, Bentley and Driver's Textbook of Pharmaceutical Chemistry. Oxford University Press, Delhi.
4. B.N. Lads, MG.Mandel and F.I. way, Fundamentals of drug metabolism & disposition, William & welking co, Baltimore USA.
5. C. Hansch, Comprehensive medicinal chemistry, Vol 1 - 6 Elsevier pergmon press, oxford
6. Daniel lednicer, Strategies For Organic Drug Synthesis And Design, John Wiley, N. Y. 1998.
7. D. Lednicer, Organic drug synthesis, Vol, 1 - 6, J.Wiley N.Y.



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